How do additives differ from anticoagulants

Heparin anticoagulation mechanism. Sodium fluoride as an anticoagulant. Possible References Used. Comments David Namwenda Reply. Riaz Reply. David Namwenda Reply. Good explanation on the anticoagulations of analytes in the Clinical Chemistry lab. Leida Ikzda Reply. Alysha Courchine Reply. Prasanna Kumar Reply. Ahmad Musa Reply. Really appreciate this sir, can you make it to PDF so that we can download it.. Thank you. Thanks for the appreciation.

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All Rights Reserved. Web development by Farhan Ahmad. No difference in capillary and venous blood values. There is anticoagulant The tube contains cells and plasma. Mix the tube well. This sample is used for hematology studies.

Can get plasma from the whole blood. Can separate the serum Serum good for biochemistry tests. There is anticoagulant Centrifuge and will get plasma. Plasma contains fibrinogen. Used for the coagulation studies Can do biochemistry tests. No anticoagulants Centrifuge to get serum Fibrinogen is absent.

This is the best sample for biochemistry tests. It can use for serology tests. Can in blood banking. After centrifugation, this is the middle layer between plasma and RBCs It contains white cells and platelets. Excretory products like urea, uric acid, creatinine, and bile. Chemical substances. Plasma values more than serum. Plasma values less than serum. No difference in the value in serum and plasma. Binds calcium Binds calcium Inhibits thrombin. Each clot activator and anticoagulant additive demonstrates specific functionality, and both manufacturers of tubes and laboratory professional strive to provide suitable interference-free sample matrices for laboratory testing.

Both manufacturers of in vitro diagnostic devices and laboratory professionals need to understand all aspects of venous blood sampling so that they do not underestimate the impact of tube additives on laboratory testing. Keywords: Blood specimen collection; anticoagulant; clot activator; patient safety; phlebotomy; tube additive. Abstract In the clinical laboratory, knowledge of and the correct use of clot activators and anticoagulant additives are critical to preserve and maintain samples in optimal conditions prior to analysis.

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